The EVIL is Not Just in the Virus, but Also in the Cure! “Side Effects May Vary” reviewed! (Tempe Digital / Blu-ray)

Posted by Steven Lewis on June 8, 2025

“Side Effects May Vary” From This Blu-ray Drug!

COVID-19 virus has the world masked up and social distancing in full effect with experimental vaccines being rushed toward a rollout. For Glenn Rollins, being under the weather now for weeks still hasn’t convinced him to inject himself with experimental Government drugs meant to combat coronavirus but when wife Janelle does everything in her persuasive power to convince him to take the vaccine, Glenn reluctantly agrees to receive the shot at his doctor visit the next day. What Glenn is given is no ordinary coronavirus vaccine, but the new Alpha-21 concoction just released for public intravenous inoculation, an rapidly tested serum that boils subjects from the inside-out. Instead of completely exploding in a pile of blood and sinew, Glenn’s rare blood type maintains a semi-rigid form and the only way he can maintain from melting into a pile of goo is to feast on the blood and meat of the living in his zombified state.

The cult director behind “The Dead Next Door” and “Robot Ninja,” J.R. Bookwalter, returns to take a hypodermic needle stab at a world-crippling pandemic horror inspired by the COVD-19 virus and how the FDA rushed to approve emergency vaccinations on U.S. citizens in a comically satirical, gore-and-goo-filled comedy-horror. The movie, “Side Effects May Vary,” is Bookwalter’s first film in over 20-years, the last being “Mega Scorpions” that only saw a streaming release due to a folding in the financing of a distribution deal. “Psycho Sisters” and “Her Name Was Crista” writer James L. Edwards, who’s collaborated with Bookwalter since the very beginning of the filmmaker’s career, pens the script and also stars in the disturbing desquamation of Glenn role. “Side Effects May Vary” is the second direct-and-writer production between Bookwalter and Edwards with the first being 1996’s “Polymorph. As like many of Bookwalter’s films, he produces under his longstanding own indie label Tempe Digital serving as executive producer alongside Edwards producing and wife Lana Bookwalter as associate producer.

I wouldn’t call Glenn Rollins a right-wing conservative antivaxxer but, instead, Glenn’s a doubter of the vaccine’s testing measures with a range of side effects from an experimental injectable could cause from a vaccine so unproven swirling inside his head. That’s the satirical concept Bookwalter and Edwards put into motion and deliver fully charged as mild-mannered Glenn gorges on the innards of family, friends, neighbors and strangers after unpleasantries arise from an untested product. The likeable Rollins rears an ugliness brought upon by pressures of vaccination, especially from his wife Janelle, played by indie horror scream queen Tina Krause (“Crimson Nights,” “Bloodletting”). Another scream queen of legendary acclamation is in on the fun with Brinke Stevens (“The Slumber Party Massacre,” “Sole Survivor”) as the saucy nosy neighbor who knows all the sexual acts by their sporty designations. We journey from the beginnings of a substance subjugation and are wiggled into a buddy cop scenario between Glenn Rollins’ best friend and former cop turned private eye Jack Murray (Drew Foriter, “Trivial”) and his former boss and one-night-stand Chief Tom Danvers (“Floyd Ewing Jr., “Robot Ninja”) and their sudden thrust into an investigation to find Glen under their distinct impressions of his character, plus that one sexual encounter between them, makes for a good dynamic of sidetracking diversion that interrupts a constant flow, which can get stale, of formality and responsibility of chasing a killer. The cast Sasha Graham (“Trivial”) as the prescribing primary care physician Dr. Fisher, Wendy Zier (“Trivial”), Tom Hoover (“Ozone”), and David Bachmeier (“Bathtub Shark Attack”) as the first scene test subject of Alpha-21’s explosive results.

A relief will wash over fans to know J.R. Bookwalter is not dead in the water when it comes to directing. A long hiatus was exactly what Bookwalter needed to get back to form after a string of mediocre horror that didn’t leave a bad taste in our mouths but wasn’t quite the standard of the Ohioan director’s carnage-laden caliber. “Side Effects May Vary” spoke to nationwide fears during the global pandemic, in a humorously horrifying way, and even extends beyond that now historical portion of our time into the forefront of our minds that we may have not have yet seen the actual long-term effects of the COVID shots, if any. The intention of “Side Effects May Vary” is not to instill fear, though does create a fraction of concern, but is more to the tune of exaggerated those once media covered and one-sided fears to the extreme by turning injected patients into boiling potato sacks of putrid cannibalism. It’s pretty damn funny and gross. To create a vibrant visual veneer, Bookwalter plays with different lighting angles and color gels of primary neon illumination that takes characters out of the real world and places them into a fantastical neon-noir that surrenders to the sexualized, the scandalous, and the scary story bits and pieces. The buddy-cop, manhunt storyline works as bodies are left as breadcrumbs for the two conflicting investigators that are on the precipice of making a final decision on Glenn Rollin’s fate while Glenn himself battles internally, both physically and emotionally, his wretched state that needs blood to slow down the process of his metaphorizing melting but his mild-manner, nice-guy identity doesn’t want to harm a soul.

Tempe Digital castrates the COVID cure scare with an incredible liquescent comedy-horror in “Side Effects May Vary” on a director’s cut Blu-ray home video. The AVC encoded, 1080p high-definition resolution, BD25 comes with a ton of color, contrast lighting, and a decent compression codec that makes the low-budget production appear a step or two up the upscale staircase. The heavy neon light cuts into the skin and textural details but scenes more naturally lit, such as in the outdoors, fair better with more granular inside a digital presentation in its original aspect ratio of 1.78:1. There are two English audio mixes available for selection and audiophile setup in a DTS-HD 5.1 Master Audio and a Dolby Digital 2.0 Stereo. The surround sound selection has a semi-fluid dynamic that works in a contained closed to medium shot arrangement and doesn’t expand to anything beyond to warrant an immersive experience aside from a healthier fidelity of the dialogue, proximity milieu, and the gruesome creature sound effects. Dialogue can get out of the reigned in alignment that breaks in with sparse unfiltered hissing but otherwise renders cleanly and clearly through the 81-minute runtime. English subtitles are available. Special features encoded are an audio commentary with director J.R Bookwalter, a Harris Theater Q&A in Pittsburgh at the Roadshow Opening Night with film guests Bookwalter, writer-star James L. Edwards, and actor Floyd Ewing Jr., a theatrical roadshow cut trailer, a teaser trailer, and the theatrical trailer. Art from the Alex Sarabia and Karl Munster collaboration gives a pulpy artistic rendition of Glenn Rollins oozing deterioration inside a clear Amaray Blu-ray with no supporting supplements other than a cropped version of the art on the disc. The not-rated, region free disc is a perfect cure for what ails you – bad indie comedy-horror done right!

Last Rites: A global pandemic killed millions of people, the silver-lining is now we can look back at that time of isolation and fear and honor those deaths with a coronavirus and rushed-cure blend act worthy of being to the likes of “Bad Taste.”

“Side Effects May Vary” From This Blu-ray Drug!

Make Do With Your God-Given EVIL! “Bad Biology” reviewed! (Severin Films / 4K UHD – Blu-ray)

Posted by Steven Lewis on March 3, 2024

“Bad Biology” on 4KUHD and Blu-ray Combo Set. Purchase Here!

Jennifer and Batz don’t know each other and live two totally different lives but they have one thing in common, they are enslaved by their abnormal sexual organs. Jennifer, a young provocative photographer, embraces her vagina’s biological differences and immensely magnified hormones whereas Batz suffers monstrously from his radical rehabilitation of a once limp manhood. The contrasts continue as Jennifer must scratch the inflamed itch to be penetrated, luring men with her insatiable lust that ultimately end in their demise with an irrepressible emotional sway, whereas the botted-up Batz’s love life is virtually bankrupt due in fear of his conscious and uncontrollable enlarged penis. When Jennifer happens upon Batz in her peripheral during a photoshoot, she finds him intriguing enough to break into his home and watch him with a prostitute. The experience left the prostitute with a continuous orgasm long after penetration was over and left Jennifer with an impression that her vagina has finally found it’s match in life.

Seventeen years. That’s how long the inactivity span was between Frank Henenlotter’s last directed film and his next. Not since 1991 did Henenlotter, the madcap mastermind behind some of the more than unusual creature-esque concepts surrounding sexuality, addiction, and childbirth in a way that sheds light on society’s blatant distaste for the odd and grotesque, profess his creative talents with his trademark dark humor and unabashed practical effects that campy the content toward much to our enjoyment again until returning to the director’s chair with the 2008 shlock-sleazy horror-comedy “Bad Biology,” cowritten alongside American rapper R.A. “The Rugged Man” Thorburn as the musicians first taste of the film industry. Shot in and around the New York metropolitan area, “Bad Biology” is also produced by Thorburn alongside associate producers Dario Correale, Nicholas Deeg, Antonia Napoli, Vinnie Paz, and star Anthony Sneed under the LLC created for Bad Biology.

Not many would take on a role with heightened sexual absurdity, especially one with a puppeteered penis on the hunt for feminine pelvic regions or where a numerous clitorises ramp up sexual drive into murderous overdrive. Yet, first time actors Charlee Danielson and Anthony Sneed seem game for the roles as lonely sexual misfits Jennifer and Batz. To debut right out the gate as a character proclaiming to have 7 clits in the very first scene can’t be easy and I’m sure a deluge of thoughts questioning just what in the ridiculous Hell did I get myself into accelerated through her thoughts but Charlee Danielson doesn’t pull punches or need a second to rethink life choices in the feed the need role of lust, sex, kill, labor, birth and repeat. Same can be said about Anthony Sneed’s slinking and desperate peculiarities for Batz and Sneed’s willingness to browbeat his own anaconda trouser snake to assert back in being control. Danielson and Sneeds have tough jobs but pull off Henenlotter and Thorburn’s grotesquely envisioned gallows humor and body horror. While the confidence is there, the experience is not resulting in a stiff, monotone performances in nearly every scene and that can dampen the story’s eccentrical principals who are just delivering the lines instead of taking the lines to heart. Being that “The Rugged Man” is a rapper, the cast is comprised of other likeminded musical artists, mostly rappers as well, with Remedy, J-Zone, Vinnie Paz, and Reef the Lost Cause along with cameos from other artists and music producers. And being a film mostly about sex, “Bad Biology” fills out the cast with models and actors very comfortable showing their skin in Vivian Sanchez, Carolyn Thompson, Brittany Moyer, Vicky Wiese, Ginger Starr, Vladislav S., and well-verse indie horror scream queen Tina Krause (“Crimson Nights”, “The Fappening”).

Outrageous with bad taste, “Bad Biology” prides itself with point-blank profaneness and kitschy special effects, a resounding typical Frank Henenlotter production as the director hasn’t seemingly lost a step in 17 years between films. Yet, the story’s infiltrated by the need to incorporate strong personality cameos and is uneven in a way that hyper focuses on Jennifer’s quest, with inner monologuing, flashbacks, and direct camera speaking surrounding her spiritual search of a satiable schlong for her specialized snatch, becomes subverted by Batz’s less significantly told story quickly summed up in introspection while being pleasured by a homemade, industrial-sized masturbator. Doesn’t quite feel Batz receives the same valued introduction in contrast to his female counterpart, but he quickly forges a more interesting path having a roid-raging, self-aware, monster cock that’s addicted to large animal anabolic steroids and is isolated from the rest of the world. As polar opposite in the way Jennifer and Batz view and handle their sexual anomalies, the pair make the perfect odd couple, like “Ghostbusters’ Key Master and Gatekeeper, but at the cost of their own stories and their inevitable hookup that becomes flattened by a steamrolling climatic slasher-esque moment that doesn’t really involve them at all, segregating the leads momentarily from their own catalytic arc that deflates the finale into a flaccidity. Most of the comedy also falls flat but the dialogue is well bulbous in the skilled rhapsody and written dialogue that shocks and awes with every depraved bluster.

Scanned in 4K from the camera negative, “Bad Biology” receives a UHD plus Blu-ray 2-disc set from Severin Films. The HEVC encoded, ultra high-definition 2160p, BD100 and the AVC encoded, high-definition 1080p, BD50 are both presented in a widescreen 1.78:1 aspect ratio. The 4K scan fills in the gaps of next stage video evolution though the gaps filled are minuscule at best. What makes the real difference is Henenlotter shooting in Super 35mm that provides a gritty grain overlay and similar, if not identical, saturation as film stock. Finer details more in the setting aspects, around darker areas, that are more illuminated by the pixel increase. Skin tones and grading are naturally set without much of a stylistic presence other than the gels used for the giant penis vision and the peering from inside-out Jennifer’s Uterine cavity. I do think facial details are not as firm, possibly smoothed too much during the restoration. The English language audio options include a lossless DTS-HD 5.1 Master Audio and a 2.0 stereo. Presenting flawless dialogue within the heavy soapboxing monologues and philosophical diatribes, “Bad Biology” promenades dialogue as an important part to the film’s machination. This doesn’t mean everything is flounders with a range of outrageous sound effects, including the gushings of childbirth, the whooshing whips of a conscious monster male member, and the squishy ins-and-outs of copulation. Spatial depths have finite proportions that relinquishes true depth to keep audiences near the action audibly. Closed caption English subtitles are optionally available. The 4K disc might have a capacity of 100 gigabytes but the format’s space on this release is quickly depleted for the feature and two audio commentary tracks – one with director Frank Henenlotter, director of photography Nick Deeg, and actor Anthony Sneed while the second commentary also includes Henenlotter and cowriter/producer R.A. The Rugged Man Thorburn. Both commentaries are also on the Blu-ray, housing over 5+ hours of special features which includes interviews with a Spook House entitled segment featuring interviews with Henenlotter, Thorburn, Deeg, production coordinator Michael Shershenovich, production manager Chaz Kangas, and David Henenlotter, an unorthodox interview between a basketball and actress Charlee Danielson In the Basement with Charlee Danielson, a lengthy back and forth question and answer between actor Anothy Sneed and cinematographer Nicholas Deeg, an interview with special effects artist Gabe Bartalos (“Frankenhooker,” “Basket Case 3”) Swollen Agenda, a behind the scenes of the film, photographer Clay Patrick McBride snapping cast and crew O-faces around Henenlotter’s apartment in F*ck Face, short film “Suck” directed by Anthony Sneed, R.A. The Rugged Man Thorburn music video for “Legendary Loser,” an imagine gallery, behind-the-scenes shots, and video covers and death stills. The standard 4K UHD release comes in the traditional black Amary case with an O-face compilation compositional cover art and has a lock-tabbed disc on each side. The release does not come with a reversible covert art or insert. Both idiosyncratic disc arts have whimsically crude caricatures of the main characters. The region free release has a runtime of 84 minutes and unrated.

Last Rites: “Bad Biology” marks a return to ungovernable psychotronic cinema for filmmaker Frank Henenlotter with new blood, a new story, and the same old objectionable orifices and organs of monstrous body horror.

“Bad Biology” on 4KUHD and Blu-ray Combo Set. Purchase Here!